It happened outside Summerhill School, in Lodge Lane, Kingswinford at about 7.10pm last night (Thursday).
Three ambulances, a senior paramedic officer and the MERIT Trauma Doctor and critical care paramedic were sent to the scene.
A West Midlands Ambulance Service said: “On arrival, ambulance staff found two motorcyclists who had been involved in a crash with a car.
“The first motorcyclist had suffered serious injuries. He was taken on blue lights to the major trauma centre at Queen Elizabeth Hospital Birmingham with the doctor travelling with the crew. Sadly, he died later at hospital.
“The other rider, a man in his 30s had suffered multiple injuries. He was treated at the scene before also being taken on blue lights to the major trauma centre at Queen Elizabeth Hospital Birmingham.
“A woman in her 40s from the car was treated for less serious injuries and was taken to Russells Hall Hospital. A man and a woman from the same car were uninjured.”